Bioavailability & Bioequivalence
Bioavailability could be a measure of the rate and extent to that a therapeutically active chemical is absorbed from a drug product into the circulation and becomes accessible at the site of action. Blood concentrations of the active ingredients and/ or their active metabolites thereby give a marker for the concentration at the positioning of action and a legitimate measure of bioavailability. If two drugs are bioequivalent, there's no clinically vital distinction in their bioavailability. Bioequivalence studies are a surrogate marker for clinical effectiveness and safety information, because it wouldn't commonly be necessary to repeat clinical studies for generic product. Bioequivalence studies typically involve single doses of a drug. The basic study methods for bioequivalence are Study design and Statistical analysis.
- Track 1-1 First Pass Metabolism
- Track 2-2 Relative Bioavailability
- Track 3-3 Absolute Bioavailability
- Track 4-4 Therapeutic Relevance
- Track 5-5 Pka and Pkd Models